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Try out PMC Labs and tell us what you think. Learn More. Method: Urine drug screen spanning a two-year period were data mined to identify those positive for benzodiazepines. When confirmatory gas chromatography-mass spectrometry determined false positives, they were subsequently cross-referenced against pharmacy records to identify patients with active prescriptions for sertraline at the time of the initial urinary drug screen.

: Of the records reviewed, were later determined to be Best dating sites in mn positives by confirmatory gas chromatography-mass spectrometry. Sixty-two of those were associated with a concomitant benzodiazepine prescription.

Of the 98 remaining, 26 were associated with a concomitant sertraline prescription. Conclusion: Our findings suggest that sertraline may be an unreported cause of false-positive benzodiazepine in a widely used screening assay. A crucial part of the examination of any psychiatric patient is an evaluation for the effects of toxic substances, including medications and drugs of abuse.

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Routine screening tests are helpful during the early stages of formulating a differential diagnosis, especially considering that many patients who use illicit substances may be untruthful about their Baton rouge local ladies histories. Positive in these screening tests usually prompt automatic and expensive confirmatory testing by gas chromatography-mass spectrometry GC-MS. The of these confirmatory tests are often delayed for several days, a less-than-ideal situation in a difficult case.

Questions about treatment?

False-positive screens for drugs of abuse can potentially hamper diagnosis and treatment. Moreover, when patients are misdiagnosed with a substance-related disorder based on false test —despite their truthful denial of substance use—the crucial therapeutic alliance may be damaged. Such potential consequences underscore the importance of knowing the validity of screening tests for drugs of abuse. A series of three false-positive benzodiazepine urine drug screen UDS associated with sertraline use Taconic Connecticut sex video our institution compelled us to research this topic further.

A review of secondary sources revealed sertraline to be a well-described cause of false-positive benzodiazepine screens.

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InRapuri et al 1 list sertraline and oxaprozin as causing false-positive screening for benzodiazepines. The table in the article contains four references, 2 — 5 but none of them implicates sertraline as a cause of false-positives.

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The Merck Index 2 purports that sertraline and oxaprozin both cause false positives in urine benzodiazepine screens; however, the text mistakenly cites a Clinical Chemistry article 7 that focuses solely on oxaprozin without mentioning sertraline. Further confusing any clinician seeking answers from the literature is a article by Vincent et al 8 that does not list sertraline as a potential agent that could cause a false-positive Do you smoke marijuana screen.

The confusion surrounding this topic stems partially from a series of articles published in the late s that compared various commercial screening assays. A study by Wu et al 9 acknowledged the cloned enzyme donor immunoassay CEDIA technique Kari jobe dating with sertraline. This issue made its first appearance in the clinical literature when Gear 10 described a series of urine toxicology screens that returned false-positive for benzodiazepines in patients who were taking sertraline.

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Without knowledge of the specific assay being used, any article proposing that sertraline is or is not an interferant of benzodiazepine screening assays is of little value. To determine the accuracy of the urine benzodiazepine screening test employed at our institution, we performed a two-year Sweet wives wants casual sex Ponderay to December retrospective analysis of UDS of both inpatient and outpatient records to identify Im looking for some good sex just which, upon confirmatory GC-MS, were determined to be false positives.

False-positive that were found to be associated with a concomitant benzodiazepine prescription were excluded. Though presence of a concomitant active benzodiazepine prescription does not necessarily indicate concomitant benzodiazepine use, the authors felt inclusion of those would obfuscate our evaluation of the association between sertraline and test. A two-year January to December retrospective analysis of UDS identified that were positive for benzodiazepines. Of those positive urine screens, were later determined to be false positive by GC-MS, yielding a positive predictive value of When cross-referenced against pharmacy records, 62 of those were associated with a concomitant, active prescription for a benzodiazepine.

Of the 98 remaining records, 26 After observing a series of false positive urine drug screens for benzodiazepines at our institution, we suspected that false-positive might be more common than many clinicians realize.

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Our findings confirm that suspicion: A widely used benzodiazepine screening test commonly produces false-positiveand Numbers game urban dictionary ificant portion of those These raise several questions. Our finding that In addition, our retrospective study only allowed for analysis of positive testsprohibiting calculation of sensitivity, specificity, and negative predictive value—values a prospective study could elucidate through confirmatory testing of all testboth positive and negative. A prospective de Gerald rogers divorce also permit some form of direct patient questioning regarding medication use, which would allow for some degree of verification of information derived from patient records.

We hope these findings will prompt others to further examine this issue through prospective studies, as we intend to do. Kevin Wife first swinger party. Nasky, Dr. George L. Cowan, Dr. Douglas R. Knittel, Dr. National Center for Biotechnology InformationU. Journal List Psychiatry Edgmont v. Psychiatry Edgmont.

NaskyDO, George L. KnittelMD. Nasky Dr. Cowan Dr. Knittel Dr. Author information Copyright and information Disclaimer. Corresponding author.

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Address Correspondence to:Kevin M. Copyright notice. This article has been cited by other articles in PMC. Keywords: false positive, screening assay, urine drug screening, benzodiazepines, sertraline. Introduction A crucial part of the examination of any psychiatric patient is an evaluation for the effects of toxic substances, including medications and drugs of abuse. METHODS To determine the accuracy of the urine benzodiazepine screening test employed at our institution, we performed Is nicki minaj dating drake now two-year January to December retrospective analysis of UDS of both inpatient and outpatient records to identify those which, upon confirmatory GC-MS, were determined to be false positives.

Open in a separate window. Contributor Information Kevin M. References 1. Curr Psychiatry. Baselt RC. Disposition of Toxic Drugs and Chemicals in Man. Mechanism of false-negative urine cannabinoid immunoassay screens by Visine eyedrops. Clin Chem. Casavant MJ. Urine drug screening in adolescents. Pediatr Clin North Am. Principles of Addiction Medicine. False-positive immunoassay for urine benzodiazepine in patients receiving oxaprozin Daypro Clin Chem. What common substances Australian teen tits cause false positives on urine screens for drugs of abuse?

J Fam Prac.

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CEDIA for screening drugs of abuse in urine and the Sofa sale orange county of adulterants. J Forensic Sci. Gear JL. False-positive toxicology screens.

J Anal Toxicol. Clin Chim Acta. False-positive rates for the qualitative analysis of urine benzodiazepines and metabolites with the reformulated Abbott multigent reagents. Support Center Support Center.

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